A medical procedure drape, for use during a diagnostic and therapeutic procedures performed on a patient supported by a patient cart, including a cover and a holder for the endoscope. The cover superimposes a portion of the patient and a portion of the patient cart. The endoscope holder is fixed to a boundary of the cover and extends above the level of the patient support surface on the patient cart. The endoscope holder retains and supports the endoscope during insertion and at other such times that the endoscopist may wish to set the endoscope aside to perform other tasks.