A nasal lavage device includes a source of saline solution, an effluent receptacle, and a nasal interface for engaging the nostrils of a user of the device. A fluid passageway is disposed to communicate the source of saline solution with the effluent receptacle through the nasal cavity of the user. The nasal interface and fluid passageways are included within a removable cartridge for communicating the saline relative to the nostrils in a first direction. A second cartridge can be inserted to communicate the flow in a second direction. The interface includes nasal pillows that form a seal against the user's nostrils.