发明授权
- 专利标题: Modified macromolescules and associated methods of synthesis and use
- 专利标题(中): 改性大分子及其相关合成和使用方法
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申请号: US10581571申请日: 2004-12-06
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公开(公告)号: US07981871B2公开(公告)日: 2011-07-19
- 发明人: Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
- 申请人: Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
- 申请人地址: US UT Salt Lake City
- 专利权人: University of Utah Research Foundation
- 当前专利权人: University of Utah Research Foundation
- 当前专利权人地址: US UT Salt Lake City
- 代理机构: King & Spalding LLP
- 代理商 Susan T. Evans
- 国际申请: PCT/US2004/040726 WO 20041206
- 国际公布: WO2005/056608 WO 20050623
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A01N25/00 ; A61K31/715 ; A61K31/727 ; A61K47/00 ; A61K9/14 ; A61K9/50 ; C07H5/04 ; C07H5/06 ; C08B37/00 ; C08B37/10
摘要:
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.