发明授权
US07985882B1 Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same
有权
使用负载型三羧酸硼氢化物试剂的还原性胺化剂组合物及其使用方法
- 专利标题： Compositions for reductive aminations utilizing supported tricarboxyborohydride reagents and methods of using the same
- 专利标题（中）： 使用负载型三羧酸硼氢化物试剂的还原性胺化剂组合物及其使用方法
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申请号： US10226637申请日： 2002-08-23
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公开(公告)号： US07985882B1公开(公告)日： 2011-07-26
- 发明人: Sukanta Bhattacharyya , Jeffrey W. Labadie , Owen W. Gooding , Sunil Rana
- 申请人： Sukanta Bhattacharyya , Jeffrey W. Labadie , Owen W. Gooding , Sunil Rana
- 申请人地址： SE Uppsala
- 专利权人： Biotage AB
- 当前专利权人： Biotage AB
- 当前专利权人地址： SE Uppsala
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP.
- 主分类号： C07C209/24
- IPC分类号： C07C209/24
摘要：
A modified solid-support for use as a supported reagent for use in reduction reactions, including reductive amination comprising a solid-support having an tetrasubstituted ammonium cation species ionically bonded to a borohydride anion species extending therefrom having the general formula: wherein P is a solid-support, S is a spacer group selected from the group consisting of alkylene, {including —(CH2)n—}, alkyleneoxy {including -0(CH2)n—}, alkylenethio {including —S(CH2)n—} and alkylenecarboxy, {including —O(O)C—(CH2)n—}, n=2-16. R1, R2, R3 and R are each independently selected from the group consisting of alkyl, cycloalkyl, haloalkyl and aryl. Y equals 1, 2 or 3. H is hydrogen or deuterium.