发明授权
US07989451B2 Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
有权
三环1,2,4-三嗪氧化物和治疗用于癌症治疗的组合物
- 专利标题： Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
- 专利标题（中）： 三环1,2,4-三嗪氧化物和治疗用于癌症治疗的组合物
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申请号： US11887368申请日： 2006-03-31
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公开(公告)号： US07989451B2公开(公告)日： 2011-08-02
- 发明人: Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- 申请人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- 申请人地址： NZ Auckland
- 专利权人： Auckland Uniservices Limited
- 当前专利权人： Auckland Uniservices Limited
- 当前专利权人地址： NZ Auckland
- 代理机构： Nixon & Vanderhye
- 优先权： NZ539152 20050331; NZ542556 20050922
- 国际申请： PCT/NZ2006/000064 WO 20060331
- 国际公布： WO2006/104406 WO 20061005
- 主分类号： A01N43/64
- IPC分类号： A01N43/64 ; A01N43/62 ; A61K31/53 ; A61K31/55 ; C07D253/08 ; C07D487/00
摘要：
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
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