发明授权
US07989640B2 Sulfonylpyrrolidine modulators of androgen receptor function and method
有权
磺酰吡咯烷酮调节剂的雄激素受体功能及方法
- 专利标题： Sulfonylpyrrolidine modulators of androgen receptor function and method
- 专利标题（中）： 磺酰吡咯烷酮调节剂的雄激素受体功能及方法
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申请号： US12880692申请日： 2010-09-13
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公开(公告)号： US07989640B2公开(公告)日： 2011-08-02
- 发明人: Lawrence G. Hamann , Yingzhi Bi , Mark C. Manfredi , Alexandra A. Nirschl , James C. Sutton
- 申请人： Lawrence G. Hamann , Yingzhi Bi , Mark C. Manfredi , Alexandra A. Nirschl , James C. Sutton
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Burton Rodney
- 主分类号： C07D207/00
- IPC分类号： C07D207/00
摘要：
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
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