发明授权
- 专利标题： Process for the preparation of a composition of genetically modified hematopoietic progenitor cells
- 专利标题（中）： 用于制备遗传修饰的造血祖细胞的组合物的方法
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申请号： US10483347申请日： 2002-07-10
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公开(公告)号： US07994144B2公开(公告)日： 2011-08-09
- 发明人: Geoffrey P. Symonds , Rafael Amado , Lun-Quan Sun , Janet Macpherson , Greg Fanning , Wayne Gerlach
- 申请人： Geoffrey P. Symonds , Rafael Amado , Lun-Quan Sun , Janet Macpherson , Greg Fanning , Wayne Gerlach
- 申请人地址： AU Eveleigh
- 专利权人： Johnson & Johnson Research Pty, Limited
- 当前专利权人： Johnson & Johnson Research Pty, Limited
- 当前专利权人地址： AU Eveleigh
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White
- 国际申请： PCT/US02/21907 WO 20020710
- 国际公布： WO03/006691 WO 20030123
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; C12N5/08 ; C12N15/63 ; C12Q1/68 ; C07H21/04
摘要：
Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.
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