发明授权
US07994181B2 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
有权
6-1H-咪唑并喹唑啉和喹啉衍生物，新型强效止痛剂和抗炎剂
- 专利标题： 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
- 专利标题（中）： 6-1H-咪唑并喹唑啉和喹啉衍生物，新型强效止痛剂和抗炎剂
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申请号： US12376080申请日： 2006-08-03
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公开(公告)号： US07994181B2公开(公告)日： 2011-08-09
- 发明人: Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
- 申请人： Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
- 申请人地址： IT Milan
- 专利权人： Rottapharm S.p.A.
- 当前专利权人： Rottapharm S.p.A.
- 当前专利权人地址： IT Milan
- 代理机构： Sughrue Mion, PLLC
- 国际申请： PCT/EP2006/065013 WO 20060803
- 国际公布： WO2008/014822 WO 20080207
- 主分类号： A61K31/517
- IPC分类号： A61K31/517
摘要：
The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases.Formula I:
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