发明授权
- 专利标题： Substituted thienopyridone compounds with antibacterial activity
- 专利标题（中）： 取代的具有抗菌活性的噻吩并吡酮化合物
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申请号： US11853314申请日： 2007-09-11
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公开(公告)号： US07994192B2公开(公告)日： 2011-08-09
- 发明人: Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
- 申请人： Joseph Guiles , Xicheng Sun , Nebojsa Janjic , Sarah Strong
- 申请人地址： US CO Boulder
- 专利权人： Crestone, Inc.
- 当前专利权人： Crestone, Inc.
- 当前专利权人地址： US CO Boulder
- 代理机构： Swanson & Bratschun, L.L.C.
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A61K31/44 ; A61K31/47 ; C07D491/02 ; C07D498/02 ; C07D471/02 ; C07D515/02 ; C07D215/00
摘要：
Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
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