The present invention relates to a system for canceling co-channel interference (CC) in a cellular orthogonal frequency division multiplexing (OFDM) system. The system canceling co-channel interference (CCI) in a cellular orthogonal frequency division multiplexing (OFDM) system comprises a mobile station (MS) receiver including a feedback generation unit for generating a feedback to a base station (BS) so as to control a transmission power of the transmitting frame of the BS, and a maximum likelihood estimation (MLE) CCI cancellation unit for canceling CCI signals arriving from neighbor cells; and a BS transmitter including a closed-loop power control unit for controlling the transmission power of the transmitting frame according to the feedback received from the MS such that received power of desired signal at the MS receiver is different from that of an interferer signal.