发明授权
- 专利标题： Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents
- 专利标题（中）： 苯并恶嗪和有用的含氮杂双环化合物可用作盐皮质激素受体调节剂
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申请号： US12162779申请日： 2007-02-01
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公开(公告)号： US07998956B2公开(公告)日： 2011-08-16
- 发明人: Toru Iijima , Yasuo Yamamoto , Hidenori Akatsuka , Takayuki Kawaguchi
- 申请人： Toru Iijima , Yasuo Yamamoto , Hidenori Akatsuka , Takayuki Kawaguchi
- 申请人地址： JP Osaka
- 专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人： Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址： JP Osaka
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2006-025403 20060202; JP2006-275917 20061010
- 国际申请： PCT/JP2007/052165 WO 20070201
- 国际公布： WO2007/089034 WO 20070809
- 主分类号： C07D265/36
- IPC分类号： C07D265/36 ; C07D413/04 ; A61K31/538 ; A61K31/5415
摘要：
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
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