A method and apparatus for transmitting and receiving a signal in a wireless communication system. The wireless communication system includes a transmitter with at least four transmit antennas and a receiver with at least one receive antenna. Space Frequency Block Coding (SFBC) processes are performed for input signals on a basis of two antenna pairs. Signal blocks whose number corresponds to the number of transmit antennas are output. A Space Time Block Coding (STBC) process is performed for the signal blocks generated according to the antenna pairs. Signals carried by single carriers are transmitted through the at least four transmit antennas mapped to the signal blocks.