发明授权
US08007823B2 Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
有权
包含可生物降解的医用聚合物的微孔制品，其制备方法及其使用方法
- 专利标题： Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
- 专利标题（中）： 包含可生物降解的医用聚合物的微孔制品，其制备方法及其使用方法
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申请号： US10552357申请日： 2004-04-02
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公开(公告)号： US08007823B2公开(公告)日： 2011-08-30
- 发明人: Basil D. Favis , Pierre Sarazin , Jianming Li , Zhenhua Yuan
- 申请人： Basil D. Favis , Pierre Sarazin , Jianming Li , Zhenhua Yuan
- 申请人地址： CA Montreal
- 专利权人： Corporation de l'Ecole Polytechnique de Montreal
- 当前专利权人： Corporation de l'Ecole Polytechnique de Montreal
- 当前专利权人地址： CA Montreal
- 代理机构： Goudreau Gage Dubuc
- 代理商 Alain A. M. Leclerc
- 国际申请： PCT/CA2004/000500 WO 20040402
- 国际公布： WO2004/087797 WO 20041014
- 主分类号： A61F2/00
- IPC分类号： A61F2/00
摘要：
The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers are melt-blended, thereby preparing a polymer blend, wherein said polymers A and B have an essentially continuous morphology. Thirdly, after cooling, polymer B and compatibilizer C are selectively extracted from the polymer blend by dissolution in a solvent that is a non-solvent of polymer A. The resulting polymeric article has an essentially continuous porosity with a void volume between 10 and 90% and a unimodal diameter distribution set to a predefined unimodal peak location. It can be used in tissue engineering, for controlled release applications or as an implantable medical device.