发明授权
- 专利标题： Macrocyclic inhibitors of hepatitis C virus
- 专利标题（中）： 丙型肝炎病毒的大环抑制剂
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申请号： US11995888申请日： 2006-07-28
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公开(公告)号： US08008251B2公开(公告)日： 2011-08-30
- 发明人: Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Mats Stefan Lindström , Pia Cecilia Kahnberg , Dmitry Antonov , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Åsa Annica Kristina Rosenquist
- 申请人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Mats Stefan Lindström , Pia Cecilia Kahnberg , Dmitry Antonov , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Åsa Annica Kristina Rosenquist
- 申请人地址： IE SE
- 专利权人： Tibotec Pharmaceuticals Ltd.,Medivir AB
- 当前专利权人： Tibotec Pharmaceuticals Ltd.,Medivir AB
- 当前专利权人地址： IE SE
- 优先权： EP05107066 20050729; EP06101278 20060203
- 国际申请： PCT/EP2006/064812 WO 20060728
- 国际公布： WO2007/014918 WO 20070208
- 主分类号： A61K38/05
- IPC分类号： A61K38/05 ; C07K5/078
摘要：
Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
公开/授权文献
- US20080200503A1 Macrocylic Inhibitors Of Hepatitis C Virus 公开/授权日：2008-08-21
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