发明授权
- 专利标题： Carbonyl reductase, gene therefor and use thereof
- 专利标题（中）： 羰基还原酶，其基因及其用途
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申请号： US11665065申请日： 2005-10-20
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公开(公告)号： US08008461B2公开(公告)日： 2011-08-30
- 发明人: Noriyuki Kizaki , Makoto Ueda , Daisuke Moriyama , Naoaki Taoka , Yoshihiko Yasohara
- 申请人： Noriyuki Kizaki , Makoto Ueda , Daisuke Moriyama , Naoaki Taoka , Yoshihiko Yasohara
- 申请人地址： JP Osaka
- 专利权人： Kaneka Corporation
- 当前专利权人： Kaneka Corporation
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2004-312365 20041027
- 国际申请： PCT/JP2005/019269 WO 20051020
- 国际公布： WO2006/046455 WO 20060504
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N9/02 ; C12P21/02 ; C12P13/00 ; C07C255/01
摘要：
The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the polypeptide and a transformant of producing the polypeptide. Another feature of the present invention is a process for producing an optically active alcohol such as (R)-3-hydroxy-3-phenylpropanenitrile by reducing a carbonyl compound such as 3-oxo-3-phenylpropanenitrile by use of the polypeptide or the transformant.
公开/授权文献
- US20090029430A1 Novel Carbonyl Reductase, Gene Therefor and Use Thereof 公开/授权日：2009-01-29