发明授权
US08008488B2 Pyrimidin-2-one compounds and their use as dopamine D3 receptor ligands
有权
嘧啶-2-酮化合物及其作为多巴胺D3受体配体的用途
- 专利标题: Pyrimidin-2-one compounds and their use as dopamine D3 receptor ligands
- 专利标题(中): 嘧啶-2-酮化合物及其作为多巴胺D3受体配体的用途
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申请号: US10548931申请日: 2004-03-12
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公开(公告)号: US08008488B2公开(公告)日: 2011-08-30
- 发明人: Hervé Geneste , Andreas Kling , Wilfried Braje , Andreas Haupt , Liliane Unger
- 申请人: Hervé Geneste , Andreas Kling , Wilfried Braje , Andreas Haupt , Liliane Unger
- 申请人地址: DE Wiesbaden
- 专利权人: Abbott GmbH & Co. KG
- 当前专利权人: Abbott GmbH & Co. KG
- 当前专利权人地址: DE Wiesbaden
- 代理机构: Polsinelli Shughart PC
- 代理商 Lisa V. Mueller
- 优先权: DE10311065 20030313
- 国际申请: PCT/EP2004/002609 WO 20040312
- 国际公布: WO2004/080981 WO 20040923
- 主分类号: C07D403/06
- IPC分类号: C07D403/06 ; C07D403/14 ; C07D401/06 ; C07D401/14 ; A61K31/505 ; A61K31/506 ; A61P25/16 ; A61P25/18 ; A61P25/24 ; A61P25/22 ; A61P25/30
摘要:
The invention relates to pyrimidin 2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula, A represents linear or branched C3-C6 alkene, which can have a double bond or triple bond and/or a group Z, which is not adjacent to the nitrogen atom of the pyrimidinone ring and is selected from O, S, C(O), NR3, C(O)NR3, NR3C(O), OC(O) and C(O)O; B represents a group of the formula (II), in which X stands for CH2 or N and Y stands for CH2 or CH2CH2, or X—Y can also jointly represent C═CH, C═CH—CH2 or CH—CH═CH; R1 and R2 are defined as cited in the description and the claims; and Ar represents an optionally substituted aromatic group. The invention also relates to a pharmaceutical agent, containing at least one compound (I) and the tautomers, derivatives and/or acid addition salts of said compound, optionally together with physiologically acceptable carriers and/or auxiliary agents. The invention also relates to the use of compounds of formula (I), and their tautomers, derivatives and pharmacologically acceptable acid addition salts for producing a pharmaceutical agent for treating diseases which respond to the influence of dopamine D3 receptor ligands.
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