发明授权
US08008497B2 1,2-dihydroquinoline derivative having (substituted phenyl or substituted heterocyclic) carbonyloxy lower alkyl group and ester-introduced phenyl group as substituents
失效
具有(取代的苯基或取代的杂环)羰基氧基低级烷基和酯引入的苯基作为取代基的1,2-二氢喹啉衍生物
- 专利标题: 1,2-dihydroquinoline derivative having (substituted phenyl or substituted heterocyclic) carbonyloxy lower alkyl group and ester-introduced phenyl group as substituents
- 专利标题(中): 具有(取代的苯基或取代的杂环)羰基氧基低级烷基和酯引入的苯基作为取代基的1,2-二氢喹啉衍生物
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申请号: US12312393申请日: 2007-11-14
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公开(公告)号: US08008497B2公开(公告)日: 2011-08-30
- 发明人: Mamoru Matsuda , Masato Nagatsuka , Toshiyuki Mori , Sachiko Kobayashi , Masatomo Kato , Miwa Takai
- 申请人: Mamoru Matsuda , Masato Nagatsuka , Toshiyuki Mori , Sachiko Kobayashi , Masatomo Kato , Miwa Takai
- 申请人地址: JP Osaka-Shi, Osaka
- 专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Osaka-Shi, Osaka
- 代理机构: Holtz, Holtz, Goodman & Chick, P.C.
- 优先权: JP2006-307651 20061114
- 国际申请: PCT/JP2007/072083 WO 20071114
- 国际公布: WO2008/059867 WO 20080522
- 主分类号: C07D215/38
- IPC分类号: C07D215/38
摘要:
The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator. The R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X represents —C(O)—, —C(O)NR8—, —S(O)2— and the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; Z represents a benzene ring or a heterocyclic ring; and P represents 0, 1, 2 or 3.
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