An uplink signal receiving method and apparatus using successive interference cancellation (SIC) in a wireless transmission system based on Orthogonal Frequency Division Multiple Access (OFDMA) are provided. The uplink signal receiving method includes storing in a provisional storage each uplink intermediate frequency (IF) signal received through an antenna of a base station and subjected to analog-to-digital conversion; analyzing the uplink IF signals stored in the provisional storage and determining a terminal to be restored; converting a data symbol of the determined terminal to be restored from a time domain into a frequency domain; performing channel/phase correction on the converted data symbol; demodulating the corrected data symbol; determining if there is a terminal to be restored; and when there is a terminal to be restored, removing the demodulated data symbol of the terminal to be restored from the temporarily stored uplink IF signals and then updating the uplink IF signals; thereby, to reducing interference between sub-carriers of the terminals caused by deviation of a center frequency of the sub-carriers of terminals constituting the uplink signal in the OFDMA-based wireless transmission system.