发明授权
- 专利标题: Tricyclic antibiotics
- 专利标题(中): 三环类抗生素
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申请号: US12988205申请日: 2009-04-14
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公开(公告)号: US08012961B2公开(公告)日: 2011-09-06
- 发明人: Christian Hubschwerlen , Georg Rueedi , John-Philippe Surivet , Cornelia Zumbrunn-Acklin
- 申请人: Christian Hubschwerlen , Georg Rueedi , John-Philippe Surivet , Cornelia Zumbrunn-Acklin
- 申请人地址: CH Allschwil
- 专利权人: Actelion Pharmaceutical Ltd.
- 当前专利权人: Actelion Pharmaceutical Ltd.
- 当前专利权人地址: CH Allschwil
- 代理机构: Hunton & Williams LLP
- 优先权: WOPCT/IB2008/051442 20080415
- 国际申请: PCT/IB2009/051541 WO 20090414
- 国际公布: WO2009/128019 WO 20091022
- 主分类号: C07D491/048
- IPC分类号: C07D491/048 ; C07D519/00 ; A61K31/33
摘要:
The invention relates to antibacterial compounds of formula (I) wherein U represents CH or N; W represents CH or N; R1 represents alkoxy, halogen or CN; ring A represents a pyrrolidin-1,3-diyl-, a piperidin-1,3-diyl or a morpholin-2,4-diyl group and B represents CH2; or ring A is selected from the groups drawn below: wherein R2 represents H, F or hydroxymethyl, and B is absent; G represents a group selected from the group consisting of —CH═CH-E, wherein Y1, Y2, Y3 and Z independently represent CH or N; Q represents O or S; and E represents phenyl which is mono- or di-substituted wherein the substituents are each independently halogen; and to pharmaceutically acceptable salts of such compounds.
公开/授权文献
- US20110039836A1 TRICYCLIC ANTIBIOTICS 公开/授权日:2011-02-17
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