发明授权
- 专利标题: Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods
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申请号: US12881234申请日: 2010-09-14
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公开(公告)号: US08012984B2公开(公告)日: 2011-09-06
- 发明人: Philip D. Stein , Sharon N. Bisaha , Saleem Ahmad , Khehyong Ngu , William N. Washburn
- 申请人: Philip D. Stein , Sharon N. Bisaha , Saleem Ahmad , Khehyong Ngu , William N. Washburn
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 John Levis; Maureen Gibbons; Jing G. Sun
- 主分类号: A61K31/4965
- IPC分类号: A61K31/4965
摘要:
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1, R2, R3, R8, and R9 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
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