发明授权
- 专利标题： Pyrrolidine aryl-ether as NK-3 receptor antagonists
- 专利标题（中）： 吡咯烷芳基醚作为NK3受体拮抗剂
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申请号： US12185157申请日： 2008-08-04
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公开(公告)号： US08012998B2公开(公告)日： 2011-09-06
- 发明人: Philippe Jablonski , Kenichi Kawasaki , Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Xihan Wu
- 申请人： Philippe Jablonski , Kenichi Kawasaki , Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Xihan Wu
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann—LA Roche Inc.
- 当前专利权人： Hoffmann—LA Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP07113942 20070807
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/14
摘要：
The invention relates to a compound of formula I wherein Ar1, Ar2, R1, R2, R3, R4, n, o, p, and q are as defined herein and to a pharmaceutically active salt thereof, including all stereoisomeric forms, individual diastereoisomers and enantiomers of the compound of formula (I) as well as racemic and non-racemic mixtures thereof. The compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
公开/授权文献
- US20090042896A1 PYRROLIDINE ARYL-ETHER AS NK3 RECEPTOR ANTAGONISTS 公开/授权日：2009-02-12
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