发明授权
US08013003B2 Di-substituted amides for enhancing glutamatergic synaptic responses
有权
用于增强谷氨酸能突触反应的二取代酰胺
- 专利标题: Di-substituted amides for enhancing glutamatergic synaptic responses
- 专利标题(中): 用于增强谷氨酸能突触反应的二取代酰胺
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申请号: US12451515申请日: 2008-05-16
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公开(公告)号: US08013003B2公开(公告)日: 2011-09-06
- 发明人: Leslie Street , Rudolf Mueller , Steven Lee
- 申请人: Leslie Street , Rudolf Mueller , Steven Lee
- 申请人地址: US CA Irvine
- 专利权人: Cortex Pharmaceuticals, Inc.
- 当前专利权人: Cortex Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Irvine
- 代理商 Henry D. Coleman; R. Neil Sudol; William J. Sapone
- 国际申请: PCT/US2008/006271 WO 20080516
- 国际公布: WO2008/143963 WO 20081127
- 主分类号: C07D413/00
- IPC分类号: C07D413/00 ; A01N43/82
摘要:
This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.