发明授权
- 专利标题: Aminoindane derivative or salt thereof
- 专利标题(中): 氨基茚满衍生物或其盐
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申请号: US12305254申请日: 2007-07-17
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公开(公告)号: US08013018B2公开(公告)日: 2011-09-06
- 发明人: Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
- 申请人: Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
- 申请人地址: JP Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Fitzpatrick, Cella, Harper & Scinto
- 优先权: JPP2006-195307 20060718
- 国际申请: PCT/JP2007/064072 WO 20070717
- 国际公布: WO2008/010481 WO 20080124
- 主分类号: A01N37/12
- IPC分类号: A01N37/12 ; A01N37/44 ; A01N33/18 ; A01N33/24 ; A61K31/24 ; A61K31/04
摘要:
Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain.A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3 -dihydro-1-benzofuran, 2,3-dihydro-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
公开/授权文献
- US20090186916A1 AMINOINDANE DERIVATIVE OR SALT THEREOF 公开/授权日:2009-07-23