发明授权
US08013143B2 RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
有权
RNA干扰介导的使用短干扰核酸（siNA）的CXCR4基因表达的抑制
- 专利标题： RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
- 专利标题（中）： RNA干扰介导的使用短干扰核酸（siNA）的CXCR4基因表达的抑制
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申请号： US12334163申请日： 2008-12-12
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公开(公告)号： US08013143B2公开(公告)日： 2011-09-06
- 发明人: James McSwiggen , Leonid Beigelman
- 申请人： James McSwiggen , Leonid Beigelman
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Laura M. Ginkel; David A. Muthard
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
This invention relates to compounds, compositions, and methods useful for modulating chemokine receptor (CXCR) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of CXCR gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of CXCR genes such as CXCR4 and CXCR7A.
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