A tire repair solution can includes a body and a cap closed on the body. The cap is provided with an intake, an outlet, and a guide tube extending from the underside of an intermediate portion into the body. Then an exterior tube is connected with the intake and also with an air compressor. A one-way air valve is fitted in the intake, and the guide tube has a through hole in its wall, and a slide block is fitted on the through hole to close it up. The outlet has a back-pressure valve fitted inside, and is connected with a connect tube for connecting with a joint to be connected with an air valve of a tire. Then the tire repair solution can is possible to be used in a normal position and in an inverted position, convenient to operate and saving time and labor largely.