发明授权
- 专利标题: Hydroxyphenyl cross-linked macromolecular network and applications thereof
- 专利标题(中): 羟基苯基交联大分子网络及其应用
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申请号: US12320613申请日: 2009-01-29
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公开(公告)号: US08021350B2公开(公告)日: 2011-09-20
- 发明人: Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
- 申请人: Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
- 申请人地址: US OH Cleveland
- 专利权人: The Cleveland Clinic Foundation
- 当前专利权人: The Cleveland Clinic Foundation
- 当前专利权人地址: US OH Cleveland
- 代理机构: Pearne & Gordon LLP
- 主分类号: C08G63/48
- IPC分类号: C08G63/48 ; C08G63/91 ; A61K31/74
摘要:
A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.