发明授权
- 专利标题： Inhibitors of TGF-R-signaling for treatment of CNS disorders
- 专利标题（中）： 抑制TGF-R信号传导治疗CNS疾病
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申请号： US10597813申请日： 2005-02-09
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公开(公告)号： US08022045B1公开(公告)日： 2011-09-20
- 发明人: Ulrich Bogdahn , Ludwig Aigner , Frank-Peter Wachs , Beate Winner , Jürgen Winkler
- 申请人： Ulrich Bogdahn , Ludwig Aigner , Frank-Peter Wachs , Beate Winner , Jürgen Winkler
- 申请人地址： DE Regensburg AT Salzburg
- 专利权人： Ulrich Bogdahn,Ludwig Aigner
- 当前专利权人： Ulrich Bogdahn,Ludwig Aigner
- 当前专利权人地址： DE Regensburg AT Salzburg
- 代理机构： J.C. Patents
- 优先权： EP04002846 20040209
- 国际申请： PCT/EP2005/001298 WO 20050209
- 国际公布： WO2005/074981 WO 20050818
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C07H21/02 ; C07H21/04
摘要：
The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia, Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.
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