发明授权
- 专利标题： Method for manufacture of escitalopram
- 专利标题（中）： 依他普仑的制备方法
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申请号： US12202522申请日： 2008-09-02
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公开(公告)号： US08022232B2公开(公告)日： 2011-09-20
- 发明人: Carla De Faveri , Florian Anton Martin Huber , Robert Dancer
- 申请人： Carla De Faveri , Florian Anton Martin Huber , Robert Dancer
- 申请人地址： DK Valby-Copenhagen
- 专利权人： H. Lundbeck A/S
- 当前专利权人： H. Lundbeck A/S
- 当前专利权人地址： DK Valby-Copenhagen
- 代理商 Stephen G. Kalinchak; Mary Catherine Di Nunzio
- 主分类号： A61K31/34
- IPC分类号： A61K31/34 ; C07D307/00
摘要：
This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallizing 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)- or (−)-(R,R)-enantiomer of O,O′-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.
公开/授权文献
- US20090069582A1 METHOD FOR MANUFACTURE OF ESCITALOPRAM 公开/授权日：2009-03-12
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