发明授权
- 专利标题： Interferon alpha antibodies and their uses
- 专利标题（中）： 干扰素α抗体及其用途
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申请号： US12551250申请日： 2009-08-31
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公开(公告)号： US08025882B2公开(公告)日： 2011-09-27
- 发明人: Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
- 申请人： Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
- 申请人地址： US NJ Princeton
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： US NJ Princeton
- 代理机构： Baker Botts L.L.P.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
公开/授权文献
- US20090324605A1 INTERFERON ALPHA ANTIBODIES AND THEIR USES 公开/授权日：2009-12-31