发明授权
US08026218B2 Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
有权
用于阿片受体激动剂和神经激肽-1受体拮抗剂的双功能止痛化合物
- 专利标题： Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
- 专利标题（中）： 用于阿片受体激动剂和神经激肽-1受体拮抗剂的双功能止痛化合物
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申请号： US11760445申请日： 2007-06-08
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公开(公告)号： US08026218B2公开(公告)日： 2011-09-27
- 发明人: Victor Hruby , Padma Nair , Takashi Yamamoto
- 申请人： Victor Hruby , Padma Nair , Takashi Yamamoto
- 申请人地址： US AZ Tucson
- 专利权人： The University of Arizona
- 当前专利权人： The University of Arizona
- 当前专利权人地址： US AZ Tucson
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 主分类号： A61K38/06
- IPC分类号： A61K38/06 ; A61P23/00 ; A61P25/04
摘要：
The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
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