Invention Grant
US08026265B2 Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors
有权
杂环取代的酮衍生物作为组蛋白脱乙酰酶（HDAC）抑制剂
- Patent Title: Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors
- Patent Title (中): 杂环取代的酮衍生物作为组蛋白脱乙酰酶（HDAC）抑制剂
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Application No.: US12086812Application Date: 2006-12-21
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Publication No.: US08026265B2Publication Date: 2011-09-27
- Inventor: Philip Jones , Jesus Maria Ontoria Ontoria , Rita Scarpelli , Raffaele Ingenito , Carsten Schultz-Fademrecht
- Applicant: Philip Jones , Jesus Maria Ontoria Ontoria , Rita Scarpelli , Raffaele Ingenito , Carsten Schultz-Fademrecht
- Applicant Address: IT Pomezia Rome
- Assignee: Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA.
- Current Assignee: Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA.
- Current Assignee Address: IT Pomezia Rome
- Agent Li Su; David A. Muthard
- Priority: GB0526107.8 20051222
- International Application: PCT/GB2006/050472 WO 20061221
- International Announcement: WO2007/072080 WO 20070628
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D233/00
Abstract:
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
Public/Granted literature
- US20100234374A1 Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors Public/Granted day:2010-09-16
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