A cache-aware Bloom filter system segments a bit vector of a cache-aware Bloom filter into fixed-size blocks. The system hashes an item to be inserted into the cache-aware Bloom filter to identify one of the fixed-size blocks as a selected block for receiving the item and hashes the item k times to generate k hashed values for encoding the item for insertion in the in the selected block. The system sets bits within the selected block with addresses corresponding to the k hashed values such that accessing the item in the cache-aware Bloom filter requires accessing only the selected block to check the k hashed values. The size of the fixed-size block corresponds to a cache-line size of an associated computer architecture on which the cache-aware Bloom filter is installed.