发明授权
- 专利标题： Enzyme-cleavable prodrug compounds
- 专利标题（中）： 可酶切的前药化合物
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申请号： US12228636申请日： 2008-08-14
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公开(公告)号： US08034787B2公开(公告)日： 2011-10-11
- 发明人: Vincent Dubois , Ann Marie Fernandez , Sanjeev Gangwar , Evan Lewis , Thomas J. Lobl , Matthew H. Nieder , Lesley B. Pickford , Andre Trouet , Geoffrey T. Yarranton
- 申请人： Vincent Dubois , Ann Marie Fernandez , Sanjeev Gangwar , Evan Lewis , Thomas J. Lobl , Matthew H. Nieder , Lesley B. Pickford , Andre Trouet , Geoffrey T. Yarranton
- 申请人地址： US NJ Princeton
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Pankaj N. Desai
- 主分类号： A61K38/06
- IPC分类号： A61K38/06 ; A61P35/00 ; C07K16/28
摘要：
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.
公开/授权文献
- US20090110753A1 Enzyme-cleavable prodrug compounds 公开/授权日：2009-04-30
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