发明授权
- 专利标题: Protein tyrosine phosphatase mutations in cancers
- 专利标题(中): 蛋白酪氨酸磷酸酶突变在癌症
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申请号: US11596349申请日: 2005-05-16
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公开(公告)号: US08039210B2公开(公告)日: 2011-10-18
- 发明人: Zhenghe Wang , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
- 申请人: Zhenghe Wang , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
- 申请人地址: US MD Baltimore
- 专利权人: The Johns Hopkins University
- 当前专利权人: The Johns Hopkins University
- 当前专利权人地址: US MD Baltimore
- 代理机构: Banner & Witcoff, Ltd.
- 国际申请: PCT/US2005/017105 WO 20050516
- 国际公布: WO2005/113824 WO 20051201
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68
摘要:
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14) affecting 26% of colorectal cancers and a smaller fraction of lung, breast and gastric cancers. Fifteen mutations were nonsense, frameshift or splice site alterations predicted to result in truncated proteins lacking phosphatase activity. Five missense mutations in the most commonly altered PTP (PTPRP) were biochemically examined and found to reduce phosphatase activity. Expression of wild-type but not a mutant PTPRT in human cancer cells inhibited cell growth. These observations suggest that the tyrosine phosphatase genes are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
公开/授权文献
- US20080039417A1 Protein Tyrosine Phosphate Mutations in Cancers 公开/授权日:2008-02-14
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