发明授权
- 专利标题： Synephrine derivatives useful as anti-inflammatory agents
- 专利标题（中）： 昔萘福林衍生物可用作抗炎剂
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申请号： US12144366申请日： 2008-06-23
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公开(公告)号： US08039501B2公开(公告)日： 2011-10-18
- 发明人: Wim Vanden Berghe , Karolien De Bosscher , Serge Van Calenbergh , Guy Haegeman , Carl Jeffrey Lacey
- 申请人： Wim Vanden Berghe , Karolien De Bosscher , Serge Van Calenbergh , Guy Haegeman , Carl Jeffrey Lacey
- 申请人地址： BE Ghent
- 专利权人： Universiteit Gent
- 当前专利权人： Universiteit Gent
- 当前专利权人地址： BE Ghent
- 代理机构： Clark & Elbing LLP
- 优先权： GB0526123.5 20051222
- 主分类号： A61K31/4164
- IPC分类号： A61K31/4164 ; A61K31/21 ; C07D233/66 ; C07C69/035 ; C07C69/773
摘要：
This invention provides compounds having the structural formula: wherein: R1 is an acyl or sulfonyl group, R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monocarboxylic acids, imidazolylcarbonyl and triazolylcarbonyl, and R3 is hydrogen or an amino-protecting group, a stereoisomer thereof, a solvate thereof, or a salt thereof, being useful as anti-inflammatory agents and anti-cancer agents.
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