发明授权
- 专利标题： Antibodies and related molecules that bind to 24P4C12 proteins
- 专利标题（中）： 结合24P4C12蛋白的抗体和相关分子
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申请号： US12205560申请日： 2008-09-05
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公开(公告)号： US08039597B2公开(公告)日： 2011-10-18
- 发明人: Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
- 申请人： Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Steven B. Kanner , Pia M. Challita-Eid , Xiao-chi Jia , Jean Gudas , Aya Jakobovits
- 申请人地址： US CA Santa Monica
- 专利权人： Agensys, Inc.
- 当前专利权人： Agensys, Inc.
- 当前专利权人地址： US CA Santa Monica
- 代理机构： Morrison & Foerster LLP
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K17/00 ; C07K17/14 ; C12P21/08 ; A61K39/395 ; A61K39/00
摘要：
Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.