Provided are an apparatus and method for negotiating a frame offset between a Base Station (BS) and a Relay Station (RS) in a wireless communication system using a multi-hop relay scheme. A communication method of a superordinate station includes, upon detecting an initial access of an relay station, determining an offset value between a frame number used in the superordinate station and a frame number to be used in the relay station; generating a message including RS frame offset information corresponding to the offset value; and transmitting the generated message to the relay station. Accordingly, since the base station and the relay station share the frame offset, the base station can transmit a specific broadcast message in advance to the relay station by considering the frame offset, and the relay station can transmit data, which has to be transmitted in synchronization with the base station at the same time point or at the same frame number, to a Mobile Station (MS) at an exact time point.