发明授权
US08043829B2 DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression
失效
编码嵌合毒素肽融合蛋白的DNA和用于重组表达的载体和哺乳动物细胞
- 专利标题： DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression
- 专利标题（中）： 编码嵌合毒素肽融合蛋白的DNA和用于重组表达的载体和哺乳动物细胞
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申请号： US11978104申请日： 2007-10-25
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公开(公告)号： US08043829B2公开(公告)日： 2011-10-25
- 发明人: John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
- 申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
- 申请人地址： US CA Thousands Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousands Oaks
- 代理商 Nisan A. Steinberg
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N15/62 ; C12N15/63 ; C12N5/10 ; C07H21/04
摘要：
Disclosed is a composition of matter comprising a ShK toxin peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
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