发明授权
- 专利标题: Pyridinoylpiperidines as 5-HT1F agonists
- 专利标题(中): 吡啶基哌啶作为5-HT1F激动剂
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申请号: US12220225申请日: 2008-07-22
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公开(公告)号: US08044207B2公开(公告)日: 2011-10-25
- 发明人: Vincent Mancuso
- 申请人: Vincent Mancuso
- 申请人地址: US IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: US IN Indianapolis
- 代理机构: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 代理商 Ivor R. Elrifi; Heidi A. Erlacher
- 主分类号: C07D401/06
- IPC分类号: C07D401/06
摘要:
The invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, substituted C3-C7 cycloalkyl-C1-C3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II; R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen, halo, or C1-C3 alkyl; R5 is hydrogen or C1-C3 alkyl; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.
公开/授权文献
- US20080300407A1 Pyridinoylpiperidines as 5-HT1F agonists 公开/授权日:2008-12-04
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