A LED lamp with 360-degree illumination includes a base, a first substrate, a stepped structure, a plurality of LEDs, and a cover. The first substrate is fixed on the base. The stepped structure is mounted on the first substrate. The stepped structure has a first annular frame connected to the first substrate, a second substrate connected to the first annular frame, and a second annular frame connected to the second substrate. The peripheral length of the second annular frame is smaller than that of the first annular frame. The plurality of LEDs is fixed to the first substrate and the second substrate and surrounds the first annular frame and the second annular frame respectively. With this arrangement, the LEDs can be arranged in a multi-storey stepped structure to generate an effect of 360-degree illumination. Also, the illumination range of the lamp can be increased.