- 专利标题: Stent coating for eluting medication
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申请号: US12603973申请日: 2009-10-22
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公开(公告)号: US08048151B2公开(公告)日: 2011-11-01
- 发明人: Robert C. O'Brien , Christine A. Frysz
- 申请人: Robert C. O'Brien , Christine A. Frysz
- 申请人地址: US NY Clarence
- 专利权人: Greatbatch Ltd.
- 当前专利权人: Greatbatch Ltd.
- 当前专利权人地址: US NY Clarence
- 代理商 Michael F. Scalise
- 主分类号: A61F2/06
- IPC分类号: A61F2/06
摘要:
A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
公开/授权文献
- US20100042204A1 Stent Coating For Eluting Medication 公开/授权日:2010-02-18
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