A method for online optimization of guidewire visibility in fluoroscopic images includes providing an digitized image acquired from a fluoroscopic imaging system, the image comprising an array of intensities corresponding to a 2-dimensional grid of pixels, detecting a guidewire in the fluoroscopic image, enhancing the visibility of the guidewire in the fluoroscopic image, calculating a visibility measure of the guidewire in the fluoroscopic image, and readjusting acquisition parameters of the fluoroscopic imaging system wherein the guidewire visibility is improved.