发明授权
US08053457B2 3-imidazolyl-indoles for the treatment of proliferative diseases
失效
3-咪唑基 - 吲哚，用于治疗增殖性疾病
- 专利标题： 3-imidazolyl-indoles for the treatment of proliferative diseases
- 专利标题（中）： 3-咪唑基 - 吲哚，用于治疗增殖性疾病
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申请号： US12593721申请日： 2008-03-27
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公开(公告)号： US08053457B2公开(公告)日： 2011-11-08
- 发明人: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
- 申请人： Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 优先权： EP07105269 20070329
- 国际申请： PCT/EP2008/053667 WO 20080327
- 国际公布： WO2008/119741 WO 20081009
- 主分类号： A61K31/397
- IPC分类号： A61K31/397 ; A61K31/5377 ; A61K31/496 ; A61K31/506 ; C07D401/14 ; C07D403/14
摘要：
The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
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