发明授权
US08067447B2 Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
有权
糖皮质激素受体，AP-1和/或NF-κB活性的调节剂及其用途
- 专利标题： Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
- 专利标题（中）： 糖皮质激素受体，AP-1和/或NF-κB活性的调节剂及其用途
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申请号： US12513192申请日： 2007-10-31
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公开(公告)号： US08067447B2公开(公告)日： 2011-11-29
- 发明人: James E. Sheppeck , John L. Gilmore , T. G. Murali Dhar , Hai-Yun Xiao
- 申请人： James E. Sheppeck , John L. Gilmore , T. G. Murali Dhar , Hai-Yun Xiao
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Burton Rodney
- 国际申请： PCT/US2007/083084 WO 20071031
- 国际公布： WO2008/057856 WO 20080515
- 主分类号： A61K31/433
- IPC分类号： A61K31/433 ; A61K31/416 ; C07D285/135 ; C07D231/56 ; C07D231/40
摘要：
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein (Ia) is heterocycle or heteroaryl; J, Ja, E, F, G, Ma, M, Q, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
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