发明授权
- 专利标题： Stable and soluble antibodies inhibiting TNFα
- 专利标题（中）： 稳定和可溶性抗体抑制TNFα
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申请号： US11916793申请日： 2006-06-06
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公开(公告)号： US08067547B2公开(公告)日： 2011-11-29
- 发明人: Stefan Ewert , Alcide Barberis , David M. Urech , Adrian Auf Der Maur , Peter Lichtlen
- 申请人： Stefan Ewert , Alcide Barberis , David M. Urech , Adrian Auf Der Maur , Peter Lichtlen
- 申请人地址： CH Zurich-Schlieren
- 专利权人： ESBATech, an Alcon Biomedical Research Unit, LLC
- 当前专利权人： ESBATech, an Alcon Biomedical Research Unit, LLC
- 当前专利权人地址： CH Zurich-Schlieren
- 代理商 Jason J. Derry
- 国际申请： PCT/CH2006/000300 WO 20060606
- 国际公布： WO2006/131013 WO 20061214
- 主分类号： C12P21/08
- IPC分类号： C12P21/08
摘要：
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
公开/授权文献
- US20090263382A1 STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA 公开/授权日：2009-10-22
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