发明授权
US08067575B2 RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
有权
RNA干扰介导使用短干扰核酸（siNA）抑制细胞周期蛋白D1基因表达
- 专利标题： RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
- 专利标题（中）： RNA干扰介导使用短干扰核酸（siNA）抑制细胞周期蛋白D1基因表达
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申请号： US12200736申请日： 2008-08-28
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公开(公告)号： US08067575B2公开(公告)日： 2011-11-29
- 发明人: James McSwiggen , Leonid Beigelman
- 申请人： James McSwiggen , Leonid Beigelman
- 申请人地址： US NJ Rahway
- 专利权人： Merck, Sharp & Dohme Corp.
- 当前专利权人： Merck, Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K31/70
摘要：
This invention relates to compounds, compositions, and methods useful for modulating cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) genes.
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