A device and method for eliminating narrow-band interference by windowing in a spread spectrum system are disclosed. The method comprises extracting N sampling points of data to perform frequency spectrum transform each time and obtaining N points of data; updating control information, comparing the energy values of the N points with the threshold within the set time period to determine the number of narrow-band interference as well as the width and location of the interference; determining the corresponding frequency domain adjusting window based on the width and location of the narrow band interference, obtaining the points within the window and the adjusted values of those points; with regard to the transformed N points during interference elimination process, setting the energy values of the points within the window during the current time period and the last period as the corresponding adjusted values, outputting the points after frequency spectrum inverse transform.