发明授权
- 专利标题: Medium-chain length fatty alcohols as stimulators of hematopoiesis
- 专利标题(中): 中链长脂肪醇作为造血刺激物
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申请号: US11663888申请日: 2005-09-29
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公开(公告)号: US08071580B2公开(公告)日: 2011-12-06
- 发明人: Christopher Penney , Lyne Gagnon , Jean Barabé
- 申请人: Christopher Penney , Lyne Gagnon , Jean Barabé
- 申请人地址: CA Laval, Quebec
- 专利权人: Prometic Biosciences Inc.
- 当前专利权人: Prometic Biosciences Inc.
- 当前专利权人地址: CA Laval, Quebec
- 代理机构: Clark & Elbing LLP
- 国际申请: PCT/CA2005/001490 WO 20050929
- 国际公布: WO2006/086871 WO 20060824
- 主分类号: A61K31/33
- IPC分类号: A61K31/33 ; A61K31/045
摘要:
Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem cell proliferation, and/or proliferation of one or more of the progenitors of red or white blood cells (e.g., erythrocyte, leukocyte, neutrophil, granulocyte, megakaryocyte, or any combination thereof). It also relates to the treatment of myelosuppression; in particular, this includes the treatment of anemia and/or neutropenia associated with chemotherapy and/or radiotherapy. Moreover, anemia arising from chronic renal failure or treatment of HIV-infected patients with AZT (zidovudine), or other inhibitors of reverse transcriptase, can be treated. Furthermore, neutropenia arising from infections, hematologic diseases, or nutritional deficiencies can be treated. It also relates to reducing drug toxicity and enhancing drug efficiency.
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