发明授权
- 专利标题： RNAi mediated expression inhibition of a cholinergic protein
- 专利标题（中）： RNAi介导胆碱能蛋白的表达抑制
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申请号： US12481180申请日： 2009-06-09
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公开(公告)号： US08071753B2公开(公告)日： 2011-12-06
- 发明人: Sylvie Berrard , Marie José Lecomte , Jacques Mallet , Julie Santamaria
- 申请人： Sylvie Berrard , Marie José Lecomte , Jacques Mallet , Julie Santamaria
- 申请人地址： FR Paris
- 专利权人： Centre National de la Recherche Scientifique
- 当前专利权人： Centre National de la Recherche Scientifique
- 当前专利权人地址： FR Paris
- 代理机构： Sheppard, Mullin, Richter & Hampton LLP
- 代理商 Don J. Pelto
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07H21/02 ; C12N15/63 ; C12N15/85 ; A61K48/00
摘要：
The present invention relates to nucleic acid sequences producing at least one functional miRNA, at least one functional shRNA and/or at least one functional siRNA, said miRNA, shRNA or siRNA being designed to silence the expression of a gene that encodes a cholinergic protein. The present invention further relates to compositions and kits comprising such nucleic acid sequences as well as to uses thereof.
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