发明授权
- 专利标题： Pharmaceutical composition of F(ab′)2 antibody fragments and a process for the preparation thereof
- 专利标题（中）： F（ab'）2抗体片段的药物组合物及其制备方法
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申请号： US12326687申请日： 2008-12-02
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公开(公告)号： US08075893B2公开(公告)日： 2011-12-13
- 发明人: Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
- 申请人： Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
- 申请人地址： MX México, D.F.
- 专利权人： Instituto Bioclon, S.A. de S.V.
- 当前专利权人： Instituto Bioclon, S.A. de S.V.
- 当前专利权人地址： MX México, D.F.
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K1/30
摘要：
The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
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